Table 3.

Toxicities of grade 3 or 4 in 62 eligible patients receiving at least 1 dose of fenretinide

Toxicity≤18 years age Dose of 2,475 mg/m2/d (n = 56)> 18 years age Dose of 1,800 mg/m2/d (n = 6)
Number of patients% patientsNumber of patients% patients
Rash*11.800
Diarrhea*11.800
Nausea*23.600
Vomiting*11.800
Bilirubin*47.100
AST (SGOT)*23.600
ALT (SGPT)*23.600
Nyctalopia*00116.7
Abdominal pain*35.400
Catheter-related infection11.800
Anorexia11.800
Muscle weakness11.800
Inner ear/hearing11.800
Epistaxis11.800
Bone pain814.300
Hemoglobin1119.6116.7
Dyspnea (shortness of breath)11.800
Infection without neutropenia23.600
Hepatic enlargement11.800
Liver dysfunction/failure (clinical)11.800
Leukocytes (total WBC)58.900
Hypoxia11.800
Weight loss23.600
Pleural effusion (nonmalignant)11.800
Lymphopenia610.700
Neutrophils/granulocytes (ANC/AGC)58.900
Platelets916.1233.3
Hypokalemia23.600
Tumor pain11.800
Hyponatremia23.600
Transfusion: platelets58.9116.7
Transfusion: PRBCs916.1116.7
Pain—Other11.800

NOTE: Only the worst toxicity grade per type per patient across all courses was counted. Also, targeted toxicities are indicated by asterisk.