Table 3.

Associations between IκBKβ polymorphismsa, CRC mortality, and all-cause mortality

CRC mortalityAll-cause mortality
Common namedbSNP IDMAF (%)Alive/censoredCRC deathsHR (95% CI) for CRC mortalityPAliveDeath from any causeHR (95% CI) for all-cause mortalityP
A>C intron 19rs11986055
AA2811091.002471421.00
AC/CC9.53150.39 (0.14–1.00)0.042880.44 (0.19–1.02)0.06
G>A exon 15R526Q
GG3121131.002751501.00
AG/AA0.20123.3 (2.62–207.7)0.040150.03 (5.7–437.2)< 0.01
C>Trs6474387
CC2631011.002301341.00
CT/TT15.048120.57 (0.28–1.13)0.0844160.57 (0.32–1.04)0.07
T>A intron 1rs3747811
TT84391.0074491.00
AT/AA69.8228750.69 (0.46–1.04)0.092011020.79 (0.55–1.14)0.21
G>Aintron 19rs10958713
GG138541.00121711.00
AG/AA55.9173600.80 (0.54–1.18)0.26153800.86 (0.62–1.21)0.40b
A>G intron 5rs9694958
AA2641011.002331321.00
AG/GG14.64813072 (0.39–1.33)0.2742190.76 (0.45–1.27)0.29
G>A intron 5rs2272733
GG247941.002171241.00
AG/AA19.665200.77 (0.45–1.29)0.3058270.76 (0.48–1.19)0.23

NOTE: Results in italics were also noteworthy at the FDR 25% level (2 SNPs for CRC-specific and 3 SNPs for all-cause mortality). Results in table above are adjusted for age, sex, and reported race at enrollment. MAF were calculated among unaffected siblings of cases.

  • aThe SNPs were ‘noteworthy' at an FDR 50% level when investigating both CRC-specific and all-cause mortality unless otherwise noted.

  • bSNP was not ‘noteworthy' at the FDR 50% level for all-cause mortality.