Table 2.

Associations between PTGS-1 polymorphismsa, CRC mortality, and all-cause mortality

CRC mortalityAll-cause mortality
Common namedbSNP IDMAF (%)Alive/censoredCRC deathsHR (95% CI) for CRC mortalityPAliveDeath from any causeHR (95% CI) for all-cause mortalityP
G>A intron 9rs1213266
 GG15.22541031.002261311.00
 AG/AA58110.48 (0.25–0.93)0.0249200.71 (0.43–1.15)0.16
G>A intron 2rs10306155b, c
 GG26.4242801.002151071.00
 AG/AA70341.62 (1.06–2.49)0.0360441.63 (1.13–2.36)< 0.01
A>G intron 8rs4836885b, d
 AA231771.002051031.00
 AG/GG26.476371.55 (1.02–2.34)0.0467461.47 (1.02–2.12)0.04
C>A exon 7L237M
 CC2981041.002631391.00
 CA/AA5.014102.09 (1.07–4.06)0.0512122.08 (1.14–3.82)0.02
G>A intron 8rs9299280c, d
 GG232771.002051041.00
 AG/AA26.680371.48 (0.98–2.25)0.0770471.44 (1.00–2.07)0.05
A>G intron 8rs6478565e
 AA207681.00183921.00
 AG/GG33.0105461.44 (0.97–2.13)0.0892591.37 (0.97–1.94)0.07
A>G intron 8rs10306163f
 AA192641.00170861.00
 AG/GG38.1118501.33 (0.89–1.97)0.16103651.29 (0.92–1.82)0.14
G>C intron 7rs4273915e
 GG210731.00186971.00
 GC/CC30.9102411.30 (0.87–1.95)0.2089541.29 (0.91–1.83)0.15
A>G intron 9rs12551233
 AA257981.002251301.00
 AG/GG15.955160.72 (0.41–1.27)0.2450210.68 (0.41–1.12)0.13
A>G intron 7rs3842798f
 AA196681.00174901.00
 AG/GG35.6116461.23 (0.83–1.84)0.30101611.24 (0.88–1.75)0.23
G>A intron 2rs12353214
 GG250861.002231131.00
 AG/AA23.962281.26 (0.80–1.98)0.3452381.36 (0.92–2.00)0.12
C>A exon 2P17L
 CC275971.002431291.00
 AC/AA12.355161.33 (0.76–2.34)0.3430201.22 (0.73–2.03)0.45g

NOTE: Results in italics were noteworthy at the FDR 25% level (6 SNPs for CRC-specific and 5 SNPs for all-cause mortality).Results in table above are adjusted for age, sex, and reported race at enrollment.MAF were calculated among unaffected siblings of cases.

  • aThe SNPs were ‘noteworthy' at an FDR 50% level when investigating both CRC-specific and all-cause mortality unless otherwise noted.

  • bSNPs are in high LD (r2 = 0.93).

  • cSNPs are in high LD (r2 = 0.87).

  • dSNPs are in high LD (r2 = 0.95).

  • eSNPs are in high LD (r2 = 0.91).

  • fSNPs are in high LD (r2 = 0.95).

  • gSNP was not ‘noteworthy' at the FRD 50% level for all-cause mortality.