Table 1.

Summary of identified miR targets in the Wnt signaling pathway illustrating redundant relationships in the functional pathway components

DesignationFrizzledEbilCBPNLKCycDPricklePLCCaMKIINFAT
PathwayCan., PCP, Ca++CanonicalPCPCalcium ion
miR
-20a+++++
-23a++
-25+++
-27a++++
-34a+++
-92a++++++
-148a++++++
-203++++
DesignationGene symbolName
FrizzledFZD4Frizzled homolog 4 (Drosophila)
FZD7Frizzled homolog 7 (Drosophila)
EbilTBL1XR1Transducin (beta)-like 1 X-linked receptor 1
CBPEP300E1A binding protein p300
NLKNLKNemo-like kinase
CycDCCND1Cyclin D1
PricklePRICKLE2Prickle homolog 2 (Drosophila)
PLCPLCB1Phospholipase C, β 1 (phosphoinositide specific)
CaMKIICAMK2ACalcium/calmodulin-dependent protein kinase II alpha
NFATNFAT5Nuclear factor of activated T-cells 5, tonicity responsive

Abbreviations: Can., Canonical pathway; PCP, Planar polarity pathway; Ca++, Calcium ion pathway.