Table 3.

Model-adjusted average ratios from baseline observed in plasma levels of biomarkers with false discovery rate–adjusted P values for days 15 and 28

Biomarker	Dose group (mg)	Day 15 fold change	Day 15 P	Day 28 fold change	Day 28 P
bFGF	200–300	1.23	0.77	1.34	0.71
	400	0.66	0.15	1.00	1.00
	500	1.83	0.30	2.55	0.10
c-KIT	200–300	1.06	0.74	1.11	0.59
	400	0.94	0.38	0.93	0.38
	500	0.75	0.04	0.88	0.35
FGF23	200–300	1.66	0.23	1.03	0.96
	400	1.68	0.00	1.94	0.00
	500	1.46	0.25	1.13	0.71
PLGF	200–300	1.37	0.41	2.03	0.05
	400	1.93	0.00	2.18	0.00
	500	1.84	0.04	2.12	0.01
sVEGFR1	200–300	0.93	0.89	1.11	0.83
	400	0.67	0.04	0.91	0.70
	500	0.85	0.70	1.19	0.69
sVEGFR2	200–300	0.81	0.22	0.84	0.30
	400	0.76	0.00	0.82	0.00
	500	0.73	0.01	0.76	0.03
VEGF	200–300	1.29	0.59	1.54	0.30
	400	1.23	0.22	1.51	0.04
	500	1.73	0.09	3.03	0.00