Table 3.

Model-adjusted average ratios from baseline observed in plasma levels of biomarkers with false discovery rate–adjusted P values for days 15 and 28

BiomarkerDose group (mg)Day 15 fold changeDay 15 PDay 28 fold changeDay 28 P
bFGF200–3001.230.771.340.71
4000.660.151.001.00
5001.830.302.550.10
c-KIT200–3001.060.741.110.59
4000.940.380.930.38
5000.750.040.880.35
FGF23200–3001.660.231.030.96
4001.680.001.940.00
5001.460.251.130.71
PLGF200–3001.370.412.030.05
4001.930.002.180.00
5001.840.042.120.01
sVEGFR1200–3000.930.891.110.83
4000.670.040.910.70
5000.850.701.190.69
sVEGFR2200–3000.810.220.840.30
4000.760.000.820.00
5000.730.010.760.03
VEGF200–3001.290.591.540.30
4001.230.221.510.04
5001.730.093.030.00