Table 3.

Association of EGFR expression with EGFR mutation

Methods of evaluation of EGFR expressionStatistics describedMutation
MutatedWild typePa
Specific antibodies for the ED of EGFR
ED IHC membraneN56370.2018
Mean48.2930.43
SEM10.798.77
ED IHC membrane and cytoplasmN56370.3296
Mean59.2046.16
SEM10.208.76
ED AQUAN41280.0068
Mean8.697.95
SEM0.180.18
Specific antibody for the internal domain of EGFR
ID IHC membraneN56370.0167
Mean192.0144.4
SEM12.7914.83
ID IHC membrane and cytoplasmN56370.0089
Mean205.3163.8
SEM9.6012.25
ID AQUAN39270.0085
Mean11.9210.94
SEM0.220.30

NOTE: The analyses were conducted for on the total population for IHC and on 70 patients for AQUA technology.

  • aIndependent, 2-sample t test for difference in mean score between responders and nonresponders. Equivalence of variance was tested.