Table 2.

Factors associated with IL-6 levels

Quartile of IL-6, pg/mL
<0.804≥0.804 to <1.098≥1.098 to <1.619≥1.619
Number of cases/controls = 23/61Number of cases/controls = 27/57)Number of cases/controls = 31/53Number of cases/controls = 37/47Pa
Control
 Age, y46 (43–51)50 (45–57)51 (46–54)54 (51–59)<0.01
 BMI,a kg/m223.1 (21.4–25.4)24.1 (22.6–25.7)24.1 (22.8–25.5)23.7 (22.3–25.7)0.18
 Triglyceride, mg/dL125 (94–149)127 (93–220)141 (109–193)128 (87–199)0.44
 Fasting insulin, μIU/mL4.1 (3.0–5.9)4.0 (2.6–7.0)4.5 (2.8–6.7)4.4 (2.7–7.2)0.91
 HOMA-IRa0.96 (0.70–1.39)0.88 (0.59–1.70)0.98 (0.66–1.55)0.97 (0.57–1.46)0.93
Colorectal adenoma
 Age, y47 (43–54)47 (45–55)53 (48–56)53 (50–57)0.02
 BMI,b kg/m222.6 (21.6–24.6)25.4 (22.7–26.7)24.5 (22.7–26.9)24.9 (23.2–26.6)0.04
 Triglyceride, mg/dL119 (73–206)170 (99–226)180 (105–231)188 (98–256)0.12
 Fasting insulin, μIU/mL3.3 (2.3–6.1)6.8 (3.8–10.4)5.8 (3.1–7.8)6.5 (4.0–10.8)<0.01
 HOMA-IRc0.76 (0.52–1.41)1.42 (0.85–2.33)1.38 (0.65–1.75)1.45 (0.93–2.39)<0.01

NOTE: Results are expressed as median (IQR).

  • aP values were evaluated by the Kruskal–Wallis test for median value difference in each of the quartile IL-6 groups in controls or individuals with colorectal adenoma.

  • bBMI is the weight in kilograms divided by the square of the height in meters.

  • cHOMA-IR = FPI (μIU/mL) × FPG (mg/dL)/405.