Table 3.

Grade 3 and 4 AEs during and after cycle 1a

PD 0332991 schedule 3/1 (n = 41)
Cycle 1After cycle 1
Adverse event, nGrade 3Grade 4Grade 3Grade 4
 Abdominal pain2000
 Failure to thrive1000
 Neck pain1000
 Peripheral sensory neuropathy1000
 Hip arthroplasty0010
 Gastrointestinal hemorrhage0010
 Blood uric acid increased0001
 Pleural effusion0010
  • aOne grade 5 event (cardiac arrest) occurred after cycle 1 and was not considered to be related to study drug.