Table 3.

ORs of colorectal adenoma according to quartiles of IL-6, insulin and HOMA-IR

Quartile (number of cases and controls)
1234
MeasurementOR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)Ptrend
IL-6, range, pg/mL<0.804≥0.804 to <1.098≥1.098 to <1.619≥1.619
 Cases/controls23/6127/5731/5337/47
 Univariate1.00 (reference)1.25 (0.64–2.43)1.55 (0.08–2.98)2.08 (1.09–3.97)0.01
 Model 1a1.00 (reference)1.26 (0.62–2.56)1.52 (0.75–3.08)2.22 (1.13–4.38)0.01
 Model 2a,b1.00 (reference)1.15 (0.53–2.31)1.47 (0.71–3.04)2.03 (1.04–4.08)0.03
 Model 3a,c1.00 (reference)1.20 (0.58–2.49)1.52 (0.74–3.15)2.06 (1.02–4.15)0.03
Insulin, range, μIU/mL<2.95≥2.95 to <4.55≥4.55 to <7.55≥7.55
 Cases/controls22/6227/5726/5843/41
 Univariate1.00 (reference)1.33 (0.68–2.60)1.26 (0.64–2.47)2.95 (1.54–5.64)<0.01
 Model 1a1.00 (reference)1.44 (0.69–2.98)1.50 (0.73–3.10)3.45 (1.73–6.87)<0.01
HOMA-IR,d range<0.66≥0.66 to <1.06≥1.06 to <1.74≥1.74
 Cases/controls23/6127/5926/5642/42
 Univariate1.00 (reference)1.21 (0.62–2.35)1.23 (0.63–2.40)2.65 (1.39–5.04)<0.01
 Model 1a1.00 (reference)1.47 (0.71–3.04)1.60 (0.77–3.31)3.19 (1.60–6.35)<0.01
  • aAdjusted for age, current smoking (yes or no), alcohol consumption (yes or no), family history of CRC (yes or no), and BMI (quartiles).

  • bFurther adjusted for HOMA-IR (quartiles).

  • cFurther adjusted for insulin (quartiles).

  • dHOMA-IR = FPI (μIU/mL) × FPG (mg/dL)/405.