Multiple-dose parameters on day 21 for the RP2D of 125 mg once daily
| Parameter | PD 0332991 125 mg (n = 4) |
|---|---|
| Tmax, h | 5.5 (2.0–9.8) |
| Cmax, ng/mL | 97.4 (41) |
| Ctrough, ng/mL | 47.0 (48) |
| AUC0–24, ng h/mL | 1,733 (42) |
| t1/2, h | 25.9 (29) |
| CL/F, L/h | 80.6 (34) |
| Vz/F, L | 2,793 (15) |
| Rac | 2.2 (1.5–2.9) |
NOTE: Data are median (range) for Tmax and Rac, arithmetic mean (% CV) for AUC0–24, CL/F, Cmax, Ctrough, and Vz/F.
Abbreviations: CL/F, apparent oral clearance; Vz/F, apparent oral volume of distribution during the terminal elimination phase following oral administration.