Table 5.

PD 0332991 pharmacokinetic parameters on all doses, single-dose, and multiple dosea

PD 0332991
Single-dose (day 1; N = 41)Multiple dose (day 8; N = 31)
Dose, mgnTmax, hCmax, ng/mLAUC0–10, ng h/mLnTmax, hCmax, ng/mLAUC0–10, ng h/mL
2534 (4–4)10 (63)58 (51)34 (2–7)16 (32)119 (32)
5034 (4–4)21 (3)134 (5)34 (2–7)36 (16)274 (15)
7574 (4–10)29 (24)199 (20)64 (4–9)59 (24)492 (27)b
10034 (4–4)47 (11)331 (17)37 (4–10)85 (11)592 (NA)c
125227 (2–24)52 (43)299 (44)134 (1–10)86 (34)724 (38)
15034 (4–4)91 (2)641 (5)37 (7–10)128 (42)1,084 (49)

NOTE: Data are median (range) for Tmax; arithmetic mean (% CV) for Cmax and AUC0–10.

  • aSingle-dose (cycle 1, day 1) and multiple dose (cycle 1, day 8) parameters for all doses.

  • bn = 5.

  • cn = 2.