Table 3.

Correlation between DC and plasma marker levels

Best responseTotal<25% Q25%–50% Q50%–75% Q>75% Qa
Quantitative cfDNA levels in plasma
DC5220 (77%)14 (56%)11 (44%)7 (30%)P = 0.004
PD476 (23%)11 (44%)14 (56%)16 (70%)
Total9926252523
Quantitative levels of KRAS mutations in plasma
DC115 (56%)2 (29%)4 (40%)0 (0%)aP = 0.16a
PD214 (44%)5 (71%)6 (60%)6 (100%)
Total3297106

NOTE: Quartiles (generated on the basis of the total cohort) were used for grouping of the patients and analyzed by χ2 test.

Abbreviation: Q, quartile.

  • aWhen dichotomizing the KRAS mutant group by the 75% quartile, a significantly higher rate of DC was revealed in the patients with level below 75% (P = 0.049); see text.