Table 1.

ALK FISH comparison before and after crizotinib on evaluable patients

Pre-crizotinibPost-crizotinib
Patient no.ALK FISH% cells positiveALK FISH patternaAbnormal ALK copy number/cellbALK FISHALK FISH% cells positiveALK FISH patternaAbnormal ALK copy number/cellbALK change
478%sR1.2 sRPositive90%sR1.5 sRSame
537%split0.4sR,sGPositive51%split0.5 sR,sGSame
686%split0.8 sR,sGPositive70%split0.8 sR,sGSame
728%split0.3 sR,sGPositive82%split1.5 sR,sGCNG
848%split0.5 sR,sGPositive66%split2.2 sR,sGCNG
9a80%sR1.2sRNegative2%NALoss
9bPositive56%sR0.9 sRSame
10c28%mix0.3 sR, 0.2 sGPositive30%mix0.3 sR, 0.2 sGSame
1148%split0.5 sR,sGPositive56%split0.7 sR,sGSame
1226%split0.3 sR,sGNegative8%NALoss
13c60%split0.6 sR, sGPositive48%split0.6 sR, sGSame
1468%sR1.2 sRPositive92%sR1.5 sRSame
  • NOTE: Bold text denotes a significant result related to the mechanism of resistance.

  • asR, single red; sG, single green; split, split red/green; mix, split red/green and single red.

  • bRounded to the nearest tenth decimal.

  • cPatients with intrinsic resistance.