Table 4.

Worst drug-related toxicity per patient (all cycles)

Adverse eventGrade IGrade IIGrade IIIGrade IV
Hematologic toxicity
 Anemia12% (5)26% (11)5% (2)2% (1)
 Lymphopenia16% (7)7% (3)2% (1)0
 Neutropenia7% (3)12% (5)2% (1)0
 Thrombocytopenia9% (4)2% (1)4% (2)2% (1)
Nausea35% (15)12% (5)––––
Vomiting28% (12)16% (7)2% (1)––
Fatigue12% (5)30% (13)5% (2)––
Fever, rigor, chills, pruritus, flu-like symptoms37% (16)9% (4)––––
Diarrhea16% (7)7% (3)––––
Anorexia7% (3)16% (7)––––
Flushing16% (7)5% (2)––––
Mucositis12% (5)2% (1)––––
Constipation7% (3)5% (2)––––
Dyspnea5% (2)2% (1)––––
Alopecia7% (3)––––––
Peritonitis (GI fistula/tumor lysis)––––––2% (1)
Pain
 Tumor pain19% (8)19% (8)14% (6)––
 Other paina37% (16)2% (1)––––
 Headache19% (8)16% (7)
Neurologic
 Muzzy head, dizziness, confusion26% (11)2% (1)––––
 Sensory neuropathy9% (4)5% (2)––––
 Ataxia2% (1)2% (1)––––
 Motor neuropathy5% (2)––––––
 Tinnitus––5% (2)––––
 Blurred vision2% (1)––2% (1)––
 Diplopia2% (1)––2% (1)––
Cardiac
 Hypertension40% (17)14% (6)5% (2)––
 Sinus tachycardia40% (17)––––2% (1)b
 QTc prolongation19% (8)12% (5)––––
 Hypotension12% (5)––2% (1)2% (1)b
 Sinus bradycardia14% (6)––––––
 Atrial fibrillation––––2% (1)––
 Ischemia––2% (1)––––

Abbreviation: GI, gastrointestinal.

  • aMusculoskeletal pain in most patients.

  • bIn relation to peritonitis.