Table 3.

Dose-limiting toxicitiesa

Patient 2415.4 mg/m2Grade III fast atrial fibrillation 5 days after first dose
Patient 2515.4 mg/m2Grade III tumor lysis and GI fistula formationb
Patient 2711 mg/m2Grade III blurred vision
Patient 2811 mg/m2Grade III hypertension and diplopia
Patient 33c11 mg/m2Grade III increased troponin level

Abbreviation: GI, gastrointestinal.

  • aWhere multiple DLTs occurred in a patient, the most clinically relevant has been quoted.

  • bResulting in grade IV peritonitis, contributing to tachycardia, thrombocytopenia, and hypotension.

  • cPatient was later found to be on antihypertensive drugs and therefore ineligible and replaced.