Table 2.

Genes and gene sets significantly associated with age (young age) in cohorts 1 (n = 1,188) and 2 (n = 2,334)

FunctionUntreated cohort (cohort 1, n = 1,188)Treated cohort (cohort 2, n = 2,334)
GenesGene setsEffect of age adjusted for data setEffect of age adjusted for all covariatesFDR of 2nd adjustmentEffect of age adjusted for data setEffect of age adjusted for all covariatesFDR of 2nd adjustmentUp- or downregulated
Apoptosis relatedFAS1.7E-046.6E-030.037.5E-043.9E-030.008down
CASP32.2E-032.2E-020.083.3E-032.5E-020.04
BAD3.8E-033.2E-020.114.0E-031.7E-020.03
MAP kinase relatedMAPK1.2E-135.8E-07<0.00011.6E-085.9E-050.0002up
mTOR/PI3K relatedPDPK13.3E-032.1E-020.082.3E-057.6E-040.002up
PIK3CA-GS1.4E-126.7E-09<0.00011.7E-115.0E-11<0.0001
BRCA relatedBRCA13.3E-043.8E-040.0032.4E-024.4E-020.06down
BRCA1 mutant5.4E-094.5E-030.025.6E-062.5E-030.006up
Stem cell relatedRANKL5.8E-081.8E-10<0.00011.3E-061.6E-06<0.0001up
MaSC8.0E-111.5E-09<0.00013.5E-183.2E-15<0.0001up
Luminal progenitorc-kit5.8E-123.3E-13<0.00017.9E-081.3E-07<0.0001up
Luminal progenitor1.7E-091.1E-030.0072.4E-051.9E-020.04up

NOTE: For complete reference list of genes and gene sets, please refer to Supplementary 8.