Table 1.

Clinical course of patients with lung cancers harboring EGFR exon 19 insertions

PatientStageResectedTKIClinical settingTTR/TTP, mo
1IAYesNone>1
2IAYesNone>7
3IIAYesErlotinibAdjuvant>42
4IIBYesNone>55
5IIBYesNone>1
6IIIAYesErlotinibNeoadjuvant and adjuvant>10
7IIIAYesGefitinibNeoadjuvant and adjuvant>48
8IIIBYesGefitinibAdjuvant38
9IVBNoAfatinibPalliative14 (PR)
10IVBNoXL647Palliative4
11IVBNoErlotinibPalliative19 (PR)
12IVBNoErlotinibPalliative50 (PR)

NOTE: > designates a patient who has not yet relapsed/progressed.

Abbreviations: NED, no evidence of disease; PR, partial response; TTP, time to progression; TTR, time to relapse.