Table 2.

Sensitivity phenotype of well-described EGFR mutations in lung cancer

PhenotypeGenotype
TKI sensitiveExon 19 deletions (41)
Exon 21 L858R (41)
Exon 21 L861Xa (9)
Exon 18 G719Xa (9)
Exon 19 insertions
Baseline resistanceExon 20 insertions (8)
Exon 20 T790Mb (9)
Acquired resistanceExon 20 T790M (11)
  • aX designates that several amino acid substitutions are possible at this site.

  • bWhen detected using conventional methods.