Table 3.

Multivariate analyses of factors that might affect the presence of EGFR, HER2, or KRAS mutations

VariableCategoryOR (95% CI)P
EGFR mutation
Age≥58 y/<58 y1.93 (1.15–3.24)0.013
StageI + II/III + IV1.46 (0.84–2.54)0.180
DifferentiationPoor/moderate + well0.64 (0.35–1.16)0.144
Histologic subtypeAcinar predominant/othersa2.10 (1.25–3.52)0.005
HER2 mutation
Age<58 y/≥58 y4.17 (1.15–15.11)0.030
StageI + II/III + IV0.72 (0.24–2.15)0.551
DifferentiationPoor/moderate + well1.65 (0.50–5.42)0.408
Histologic subtypeIMA/othersb5.81 (1.37–24.72)0.017
KRAS mutation
Age<58 y/≥58 y2.32 (0.42–12.98)0.337
StageI + II/III + IV1.16 (0.22–6.10)0.858
DifferentiationPoor/moderate + well6.91 (1.24–38.60)0.028
Histologic subtypeIMA/othersb14.30 (2.15–95.10)0.006
  • aOthers, subtypes other than acinar predominant.

  • bOthers, subtypes other than IMA.