Table 3.

Treatment-related adverse events

Grades 1–2Grades 3–4
Adverse eventNo.%No.%
Rash2359718
Diarrhea174425
Fatigue164138
Peripheral edema123125
Elevated liver enzymes92300
Electrolyte abnormalities71800
Nausea/vomiting71800
Stomatitis61513
Dyspnea51300

NOTE: All enrolled patients are included in the assessment for toxicity (N = 39). Four patients who died on study are discussed in the text including 2 pulmonary deaths.