Table 2.

Administration protocols of first-in-human phase I drugs

Study no.Molecular targetsSingle agent/combinationNTrial registration ID
1PI3K (pan-class I)Single agent9NCT00962611
2PI3K/mTORC1Single agent41NCT00485719
3AKTSingle agent33NCT00670488
4mTORC1Single agent15NCT00694083
5mTORC1Single agent11NCT01071304
6p70S6KSingle agent15NCT01394003
7MEK1/2Single agent14NCT00959127
8p38MAPKSingle agent22NCT01393990
9AKT + MEK1/2Combination27NCT01021748
10AKT + MEK1/2Combination18NCT01138085
11mTORC1 + MEK1/2Combination31NCT00955773
Total236

Abbreviations: p38MAPK, p38 mitogen-activated protein kinase; p70S6K, ribosomal protein S6 kinase.