Table 3.

Clinical, pathologic, and molecular data of colorectal cancers with concomitant PIK3CA mutations in both exons 9 and 20

Case IDAgeSexNo. of first-degree relatives with colorectal cancerTumor locationTNM stageSize (cm)Tumor gradeExon 9Nucleotide changeExon 20Nucleotide changeKRASBRAFLINE-1 methylation (%)MSICIMPaTP53 expressionFollow-up (mo)Clinical outcome
183Male0AT2N0M04.2Lowc.1633G > Ac.3140A > Tc.35G > TWT59MSSL(–)162DFO
269Male1ST3N2M13.5Highc.1633G > Ac.3129G > Tc.35G > AWT63MSSL(+)11DOD
368Female1SFT3N0M04.5Lowc.1624G > Ac.3137C > AWTWT49MSSL(–)113DFO
460Female0TT3N2M04.5Highc.1633G > Ac.3136G > Ac.35G > AWT67MSSH(+)36DOD
582Male0RT3N1M13.0Highc.1624G > Ac.3140A > Gc.38G > AWT59MSSL(–)13DOD
c.1631C > A
677Male1AT2N0M02.0Lowc.1633G > Ac.3140A > GWTc.1799T > A64HHNA10DOD
788Male1AT2N0M04.3Lowc.1633G > Ac.3140A > Gc.34G > TWT74MSSHNA76DFO

Abbreviations: A, ascending colon; DFO, died from other causes; DOD, died of disease (colorectal cancer); H, MSI high; NA, not available; R, rectum; S, sigmoid; SF, splenic flexure; T, transverse colon; WT, wild type.

aCIMP status; H, CIMP high; L, CIMP low.