Table 2.

Connexin 47 variation seen in secondary lymphedema

cDNAΔntAmino acidProtein locationComment
bp 436G→AG 146 SCytoplasmic loopIdentified in primary lymphedema also reported in PMLD
bp 547G→TG 183 CCytoplasmic loop
bp 1141C→TP 381 SC terminal
bp1225C→TH 409 YC terminalSister with secondary lymphedema following breast cancer
bp 585C→TH195HCytoplasmic loopPolymorphism