Table 2.

Univariate analyses of baseline biomarker concentrations and demographic/clinical variables

HGFVEGFs-c-KITAng2IGF-2
Demographic or clinical variableMean level, pg/mLP valueMean level, pg/mLP valueMean level, ng/mLP valueMean level, pg/mLP valueMean level, pg/mLP value
Sex
 Male2,272.2NS94.2NS12.0NS7,672.5NS840.7<0.0001
 Female2,754.293.212.48,175.01,374.7
Age
 <652,768.5NS106.0NS12.5NS7,850.3NS972.70.0182
 ≥652,770.686.111.97,668.6873.6
ECOG PS
 02,778.6NS82.80.04713.00.0036,608.8<0.0001935.4NS
 1 or 22,760.3106.011.18,917.6889.9
MVI and/or EHS
 Absent2,635.4NS81.9NS12.6NS6,800.00.018885.2NS
 Present2,830.999.511.98,162.2925.6
AFP
 ≤Median2,549.50.01197.4NS12.1NS6,887.80.0015947.2NS
 >Median2,989.090.712.18,590.7879.2
MVI
 No2,570.40.00294.4NS11.9NS6,889.6<0.0001960.80.001
 Yes3,096.493.412.49,133.1835.1
Albumin
 ≤Median3,145.5<0.00198.4NS12.80.0329,273.2<0.0001754.6<0.0001
 >Median2,398.889.711.46,189.21,073.0
Alkaline phosphatase
 ≤Median2,472.1<0.00178.80.00411.8NS6,305.7<0.0001929.6NS
 >Median3,071.2109.612.49,195.0896.2
Total bilirubin
 ≤Median2,412.8<0.001107.30.01610.7<0.00016,857.30.00031,056.9<0.0001
 >Median3,122.281.113.58,598.9771.7

Abbreviations: EHS, extrahepatic spread; MVI, macroscopic vascular invasion; NS, not significant (P > 0.05).