Table 2.

Univariate analyses of baseline biomarker concentrations and demographic/clinical variables

	HGF		VEGF		s-c-KIT		Ang2		IGF-2
Demographic or clinical variable	Mean level, pg/mL	P value	Mean level, pg/mL	P value	Mean level, ng/mL	P value	Mean level, pg/mL	P value	Mean level, pg/mL	P value
Sex
Male	2,272.2	NS	94.2	NS	12.0	NS	7,672.5	NS	840.7	<0.0001
Female	2,754.2		93.2		12.4		8,175.0		1,374.7
Age
<65	2,768.5	NS	106.0	NS	12.5	NS	7,850.3	NS	972.7	0.0182
≥65	2,770.6		86.1		11.9		7,668.6		873.6
ECOG PS
0	2,778.6	NS	82.8	0.047	13.0	0.003	6,608.8	<0.0001	935.4	NS
1 or 2	2,760.3		106.0		11.1		8,917.6		889.9
MVI and/or EHS
Absent	2,635.4	NS	81.9	NS	12.6	NS	6,800.0	0.018	885.2	NS
Present	2,830.9		99.5		11.9		8,162.2		925.6
AFP
≤Median	2,549.5	0.011	97.4	NS	12.1	NS	6,887.8	0.0015	947.2	NS
>Median	2,989.0		90.7		12.1		8,590.7		879.2
MVI
No	2,570.4	0.002	94.4	NS	11.9	NS	6,889.6	<0.0001	960.8	0.001
Yes	3,096.4		93.4		12.4		9,133.1		835.1
Albumin
≤Median	3,145.5	<0.001	98.4	NS	12.8	0.032	9,273.2	<0.0001	754.6	<0.0001
>Median	2,398.8		89.7		11.4		6,189.2		1,073.0
Alkaline phosphatase
≤Median	2,472.1	<0.001	78.8	0.004	11.8	NS	6,305.7	<0.0001	929.6	NS
>Median	3,071.2		109.6		12.4		9,195.0		896.2
Total bilirubin
≤Median	2,412.8	<0.001	107.3	0.016	10.7	<0.0001	6,857.3	0.0003	1,056.9	<0.0001
>Median	3,122.2		81.1		13.5		8,598.9		771.7

Abbreviations: EHS, extrahepatic spread; MVI, macroscopic vascular invasion; NS, not significant (P > 0.05).