Table 3.

Prognostic relevance of IGKC determined by qRT-PCR in paraffin-embedded tumor tissue of patients (n = 330) with node-negative breast cancer

PHR (95% CI)
Univariate Cox analysis of MFI
IGKC (continuous variable)0.0040.882 (0.809–0.960)
Multivariate Cox analysis of MFI adjusted to established clinical factors
Age (<50 vs. >50 y)0.3070.944 (0.593–1.501)
pT stage (<2 vs. >2cm)0.8800 964 (0.601–1.547)
Histologic grade (grade 3 vs. Grades 1 and 2)<0.0013.853 (2.386–6.238)
ER and PR (negative vs. positive)0.1361.533 (0.874–2.690)
ERBB2 status (positive vs. negative)0.4051.277 (0.718–2.270)
IGKC (continuous variable)0.0010.871 (0.805–0.944)