Table 3.

HRs and 95% CIs from univariate and multivariate Cox proportional hazards regression models

UnivariateMultivariate
VariableHR (95% CI)PHR (95% CI)P
Metformin use0.68 (0.52–0.89)0.0040.64 (0.48–0.86)0.003
Tumor size, cm1.15 (1.07–1.24)<0.0011.04 (0.96–1.14)0.359
Tumor site (tail)1.42 (1.21–2.00)0.0450.75 (0.48–1.17)0.200
Stage
 Resectable1.001.00
 Unresectable3.10 (2.11–4.55)<0.0013.05 (2.01–4.63)<0.001
 Metastatic5.38 (3.64–7.94)<0.0015.27 (3.31–8.40)<0.001
CA-19-9, U/mL
 0—471.001.00
 >47–1,0001.75 (1.16–2.64)0.0081.57 (1.02–2.44)0.039
 >1,0003.29 (2.13–5.06)<0.0012.22 (1.39–3.55)0.001
Performance status
 01.001.00
 11.34 (0.92–1.96)0.1300.92 (0.60–1.39)0.682
 21.99 (1.23–3.21)0.0050.94 (0.55–1.61)0.814
 32.73 (1.30–5.75)0.0082.49 (1.11–5.60)0.028