Table 1.

Associations between tumor leukocyte subpopulations with presence of MCPyV DNA in tumor

Tumor MCPyV DNA status
Cell type or ratioNumber of tumors studiedaDNA positiveMedian (range)/HPF; (No.)bDNA negativeMedian (range)/HPF; (No.)bP
CD3+1165.3 (0–65.0); (85)3.3 (0.3–61.7); (31)0.014
CD4+903.7 (0–25.0); (65)2.7 (0–8.3); (25)0.094
CD8+963.7 (0–18.0); (69)2.3 (0–14.0); (27)0.048
CD16+ (small)962.3 (0–24.7); (69)1.0 (0–7.0); (27)0.019
FoxP3+972.0 (0–63.3); (70)1.3 (0–64.0); (27)0.037
CD68+1165.3 (0–17.7); (85)4.0 (0.3–14.0); (31)0.026
CD163+1153.7 (0–11.0); (84)3.0 (0–7.7); (31)0.278
CD8+/CD4+ ratio900.9 (0–15.3); (65)0.6 (0–6.4); (25)0.093
CD8+/FoxP3+ ratio971.7 (0–50.0); (70)1.4 (0–50.0); (27)0.741
  • aData was missing or not interpretable for 26, 20, 20, 19, 21, and 1 tumor in immunostaining for CD4, CD8, CD16, FoxP3, and CD163, respectively.

  • bNumber of tumors studied.