Relationship between expression levels of JWA and clinicopathologic features of the individuals in 3 cohorts of gastric cancers treated with surgery alone
| Variables | Training cohort (n = 80 cases) | Testing cohort (n = 374 cases) | Validation cohort (n = 385 cases) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low (%) | High (%) | Pa | Low (%) | High (%) | Pa | Low (%) | High (%) | Pa | |
| All patients | 50 (62.5) | 30 (37.5) | 166 (44.4) | 208 (55.6) | 195 (50.6) | 190 (49.4) | |||
| Age, y | 0.051 | 0.331 | 0.182 | ||||||
| ≤65 | 43 (86.0) | 20 (66.7) | 111 (66.9) | 129 (62.0) | 92 (47.2) | 76 (40.0) | |||
| >65 | 7 (14.0) | 10 (33.3) | 55 (33.1) | 79 (38.0) | 103 (52.8) | 114 (60.0) | |||
| Gender | 0.595 | 0.442 | 0.225 | ||||||
| Males | 36 (72.0) | 24 (80.0) | 112 (67.5) | 148 (71.2) | 145 (74.4) | 152 (80.0) | |||
| Females | 14 (28.0) | 6 (20.0) | 54 (32.5) | 60 (28.8) | 50 (25.6) | 38 (20.0) | |||
| Depth of invasion | 0.063 | 0.004 | 0.040 | ||||||
| T1/T2 | 1 (2.0) | 4 (13.3) | 21 (12.7) | 51 (24.5) | 55 (28.2) | 73 (38.4) | |||
| T3/T4 | 49 (98.0) | 26 (86.7) | 145 (87.3) | 157 (75.5) | 140 (71.8) | 117 (61.6) | |||
| Lymph node metastasis | <0.001 | <0.001 | 0.003 | ||||||
| N0 | 0 (0.0) | 20 (66.7) | 21 (12.7) | 83 (39.9) | 60 (30.8) | 87 (45.8) | |||
| N1/N2/N3 | 50 (100.0) | 10 (33.3) | 145 (87.3) | 125 (60.1) | 135 (69.2) | 103 (54.2) | |||
| Distant metastasis | 0.001 | 0.820 | 0.259 | ||||||
| M0 | 35 (70.0) | 30 (100.0) | 158 (95.2) | 199 (95.7) | 186 (95.4) | 186 (97.9) | |||
| M1 | 15 (30.0) | 0 (0.0) | 8 (4.8) | 9 (4.3) | 9 (4.6) | 4 (2.1) | |||
| TNM stage | <0.001 | <0.001 | 0.001 | ||||||
| I | 0 (0.0) | 9 (30.0) | 5 (3.0) | 35 (16.8) | 38 (19.5) | 56 (29.5) | |||
| II | 3 (6.0) | 15 (50.0) | 25 (15.0) | 56 (26.9) | 38 (19.5) | 51 (26.8) | |||
| III | 29 (58.0) | 4 (13.3) | 104 (62.7) | 94 (45.2) | 110 (56.4) | 82 (43.2) | |||
| IV | 18 (36.0) | 2 (6.7) | 32 (19.3) | 23 (11.1) | 9 (4.6) | 1 (0.5) | |||
| Tumor diameter | 0.495 | <0.001 | 0.124 | ||||||
| ≤5 cm | 24 (48.0) | 17 (56.7) | 47 (28.3) | 104 (50.0) | 101 (51.8) | 114 (60.0) | |||
| >5 cm | 26 (52.0) | 13 (43.3) | 119 (71.7) | 104 (50.0) | 94 (48.2) | 76 (40.0) | |||
| Histologic typeb | 0.021 | <0.001 | <0.001 | ||||||
| Intestinal | 21 (42.0) | 21 (70.0) | 71 (42.8) | 141 (67.8) | 58 (29.7) | 100 (52.6) | |||
| Diffuse | 29 (58.0) | 9 (30.0) | 95 (57.2) | 67 (32.2) | 135 (69.2) | 89 (46.8) | |||
| XRCC1 expression | <0.001 | <0.001 | <0.001 | ||||||
| Low | 44 (88.0) | 7 (23.3) | 143 (86.1) | 34 (16.3) | 113 (57.9) | 70 (36.8) | |||
| High | 6 (12.0) | 23 (76.7) | 23 (13.9) | 174 (83.7) | 82 (42.1) | 120 (63.2) | |||