Table 2.

Multivariate Cox regression analysis of JWA, XRCC1, or JWA/XRCC1 expression and clinicopathologic variables predicting survival in 3 cohorts of gastric cancers treated with surgery alone

Training cohort (n = 80 cases)Testing cohort (n = 374 cases)Validation cohort (n = 385 cases)
VariablesHR (95% CI)PaHR (95% CI)PaHR (95% CI)Pa
JWA
Age (≤65 vs. >65)1.53 (0.76–3.08)0.2381.16 (0.90–1.51)0.2500.81 (0.61–1.06)0.125
 Gender (male vs. female)1.69 (0.95–3.02)0.0760.95 (0.73–1.25)0.7331.04 (0.75–1.45)0.801
 Histologic type (diffuse vs. intestinal)0.92 (0.54–1.56)0.7570.94 (0.72–1.21)0.6141.35 (0.99–1.84)0.058
 Tumor diameter (≤5cm vs. >5cm)1.29 (0.77–2.17)0.3301.58 (1.18–2.14)0.0031.66 (1.25–2.21)0.001
 TNM stage (I–II vs. III/IV)1.09 (0.42–2.86)0.8591.41 (1.01–1.97)0.0444.07 (2.86–5.80)<0.001
 JWA expression (low vs. high)0.20 (0.08–0.51)0.0010.16 (0.11–0.21)<0.0010.67 (0.50–0.89)0.006
XRCC1
 Age (≤65 vs. >65)1.69 (0.85–3.35)0.1351.14 (0.88–1.48)0.3320.80 (0.61–1.05)0.111
 Gender (male vs. female)1.52 (0.86–2.69)0.1531.02 (0.78–1.34)0.8701.05 (0.75–1.46)0.782
 Histologic type (diffuse vs. intestinal)0.94 (0.54–1.63)0.8240.90 (0.69–1.17)0.4251.35 (1.00–1.85)0.057
 Tumor diameter (≤5cm vs. >5cm)1.01 (0.59–1.70)0.9831.49 (1.11–2.01)0.0081.62 (1.22–2.16)0.001
 TNM stage (I–II vs. III/IV)2.80 (1.37–5.71)0.0051.40 (1.00–1.94)0.0494.15 (2.92–5.90)<0.001
 XRCC1 expression (low vs. high)0.36 (0.19–0.69)0.0020.16 (0.12–0.22)<0.0010.72 (0.54–0.96)0.025
JWA/XRCC1
 Age (≤65 vs. >65)1.53 (0.76–3.08)0.2371.18 (0.91–1.54)0.2150.81 (0.61–1.07)0.138
 Gender (male vs. female)1.57 (0.88–2.79)0.1280.96 (0.73–1.26)0.7661.07 (0.77–1.49)0.692
 Histologic type (diffuse vs. intestinal)0.88 (0.51–1.52)0.6480.83 (0.64–1.07)0.1561.31 (0.96–1.79)0.088
 Tumor diameter (≤5cm vs. >5cm)1.04 (0.62–1.76)0.8711.45 (1.08–1.96)0.0151.61 (1.20–2.14)0.001
 TNM stage (I–II vs. III/IV)1.49 (0.63–3.52)0.3641.27 (0.90–1.78)0.1703.97 (2.79–5.64)<0.001
 JWA/XRCC1 expression (both low vs. one high)0.34 (0.13–0.86)0.0230.55 (0.40–0.76)<0.0010.90 (0.66–1.23)0.495
 (both low vs. both high)0.21 (0.08–0.50)<0.0010.09 (0.06–0.13)<0.0010.51 (0.34–0.75)0.001
  • aMultivariate Cox regression analysis including age, gender, TNM stage, tumor diameter, histologic type, JWA or XRCC1 or combined 2 proteins expression status.