Table 2.

Multivariate Cox regression analysis of JWA, XRCC1, or JWA/XRCC1 expression and clinicopathologic variables predicting survival in 3 cohorts of gastric cancers treated with surgery alone

	Training cohort (n = 80 cases)		Testing cohort (n = 374 cases)		Validation cohort (n = 385 cases)
Variables	HR (95% CI)	P^a	HR (95% CI)	P^a	HR (95% CI)	P^a
JWA
Age (≤65 vs. >65)	1.53 (0.76–3.08)	0.238	1.16 (0.90–1.51)	0.250	0.81 (0.61–1.06)	0.125
Gender (male vs. female)	1.69 (0.95–3.02)	0.076	0.95 (0.73–1.25)	0.733	1.04 (0.75–1.45)	0.801
Histologic type (diffuse vs. intestinal)	0.92 (0.54–1.56)	0.757	0.94 (0.72–1.21)	0.614	1.35 (0.99–1.84)	0.058
Tumor diameter (≤5cm vs. >5cm)	1.29 (0.77–2.17)	0.330	1.58 (1.18–2.14)	0.003	1.66 (1.25–2.21)	0.001
TNM stage (I–II vs. III/IV)	1.09 (0.42–2.86)	0.859	1.41 (1.01–1.97)	0.044	4.07 (2.86–5.80)	<0.001
JWA expression (low vs. high)	0.20 (0.08–0.51)	0.001	0.16 (0.11–0.21)	<0.001	0.67 (0.50–0.89)	0.006
XRCC1
Age (≤65 vs. >65)	1.69 (0.85–3.35)	0.135	1.14 (0.88–1.48)	0.332	0.80 (0.61–1.05)	0.111
Gender (male vs. female)	1.52 (0.86–2.69)	0.153	1.02 (0.78–1.34)	0.870	1.05 (0.75–1.46)	0.782
Histologic type (diffuse vs. intestinal)	0.94 (0.54–1.63)	0.824	0.90 (0.69–1.17)	0.425	1.35 (1.00–1.85)	0.057
Tumor diameter (≤5cm vs. >5cm)	1.01 (0.59–1.70)	0.983	1.49 (1.11–2.01)	0.008	1.62 (1.22–2.16)	0.001
TNM stage (I–II vs. III/IV)	2.80 (1.37–5.71)	0.005	1.40 (1.00–1.94)	0.049	4.15 (2.92–5.90)	<0.001
XRCC1 expression (low vs. high)	0.36 (0.19–0.69)	0.002	0.16 (0.12–0.22)	<0.001	0.72 (0.54–0.96)	0.025
JWA/XRCC1
Age (≤65 vs. >65)	1.53 (0.76–3.08)	0.237	1.18 (0.91–1.54)	0.215	0.81 (0.61–1.07)	0.138
Gender (male vs. female)	1.57 (0.88–2.79)	0.128	0.96 (0.73–1.26)	0.766	1.07 (0.77–1.49)	0.692
Histologic type (diffuse vs. intestinal)	0.88 (0.51–1.52)	0.648	0.83 (0.64–1.07)	0.156	1.31 (0.96–1.79)	0.088
Tumor diameter (≤5cm vs. >5cm)	1.04 (0.62–1.76)	0.871	1.45 (1.08–1.96)	0.015	1.61 (1.20–2.14)	0.001
TNM stage (I–II vs. III/IV)	1.49 (0.63–3.52)	0.364	1.27 (0.90–1.78)	0.170	3.97 (2.79–5.64)	<0.001
JWA/XRCC1 expression (both low vs. one high)	0.34 (0.13–0.86)	0.023	0.55 (0.40–0.76)	<0.001	0.90 (0.66–1.23)	0.495
(both low vs. both high)	0.21 (0.08–0.50)	<0.001	0.09 (0.06–0.13)	<0.001	0.51 (0.34–0.75)	0.001

↵^aMultivariate Cox regression analysis including age, gender, TNM stage, tumor diameter, histologic type, JWA or XRCC1 or combined 2 proteins expression status.