Table 2.

A375 melanoma xenograft PD parameter estimates from integrated population PK–PD-efficacy model

ParameterPopulation mean (%SE)Interindividual variance (%SE)
 kng, d−10.0828 (10.7)0.426 (26.9)
 Kmax, d−10.201 (0.4)Fixed
 K (%I)50 (%pERK decrease)50.2 (0.7)Fixed
 n11.5 (0.4)Fixed
Initial tumor volume, mm3117 (3.1)0.024 (37.6)
Residual variability
 Proportional error σprop (%)0.113 (19.3)
 Additive error σadd (mm3)15.2 (14.8)