Table 3.

Highly inverse-correlated miRNA and putative target gene pairs

miRNA namemRNA nameGenbank accessionDescriptioncorrelation coefficientaPaPathway (KEGG)b
hsa-miR-17ACPPNM_001099Acid phosphatase, prostate–0.85490.000200361: gamma-Hexachlorocyclohexane degradation, 00740: Riboflavin metabolism
hsa-miR-18aHTR1DNM_0008645-Hydroxytryptamine (serotonin) receptor 1D–0.84670.000304080: Neuroactive ligand–receptor interaction
hsa-miR-17DAPK2NM_014326Death-associated protein kinase 2–0.80730.000905200: Pathways in cancer, 05219: Bladder cancer
hsa-miR-17LY75NM_002349Lymphocyte antigen 75–0.80720.0009
hsa-miR-17TRIM7NM_203297Tripartite motif-containing 7–0.77940.0017
hsa-miR-19bCASP7NM_033338Caspase 7, apoptosis-related cysteine peptidase–0.77280.002004210: Apoptosis, 05010: Alzheimer's disease
hsa-miR-17SHROOM1NM_133456shroom family member 1–0.75530.0028
hsa-miR-19aPDE11ANM_016953Phosphodiesterase 11A–0.74060.003800230: Purine metabolism
hsa-miR-20aSYT13NM_020826Synaptotagmin XIII–0.73850.0039
hsa-miR-18aPDE11ANM_016953Phosphodiesterase 11A–0.73770.004000230: Purine metabolism
hsa-miR-18aSLC18A1NM_003053Solute carrier family 18 (vesicular monoamine), member 1–0.73420.004305012: Parkinson's disease
hsa-miR-19aCLIC5NM_016929Chloride intracellular channel 5–0.72310.0052
hsa-miR-19aARFIP1NM_001025595ADP-ribosylation factor interacting protein 1–0.72290.0052
hsa-miR-19aKCNV1NM_014379Potassium channel, subfamily V, member 1–0.71900.0056
hsa-miR-18aMYO7BBC035615Myosin VIIB–0.71510.0060
hsa-miR-17PKDREJNM_006071Polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)–0.71080.0065
hsa-miR-19aSTX18NM_016930syntaxin 18–0.70680.006904130: SNARE interactions in vesicular transport
hsa-miR-17TRIM68NM_018073Tripartite motif-containing 68–0.70580.0070
hsa-miR-18aSLC35D2NM_007001Solute carrier family 35, member D2–0.70510.0071
hsa-miR-17TCF7NM_003202Transcription factor 7(T-cell specific, HMG box)–0.70230.007404310: Wnt signaling pathway, 04520: Adherens junction, 04916: Melanogenesis, 05200: Pathways in cancer, 05210: Colorectal cancer, 05213: Endometrial cancer, 05215: Prostate cancer, 05216: Thyroid cancer, 05217: Basal cell carcinoma, 05221: Acute myeloid leukemia, 05412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa-miR-18aSLC5A9NM_001011547Solute carrier family 5 (sodium/glucose cotransporter), member 9–0.70090.0076
hsa-miR-19aABLIM1NM_001003408Actin binding LIM protein 1–0.69660.008204360: Axon guidance
hsa-miR-18aCASP7NM_033338Caspase 7, apoptosis-related cysteine peptidase–0.69600.008204210: Apoptosis, 05010: Alzheimer's disease
hsa-miR-20aH2AFJNM_177925H2A histone family, member J–0.69390.008505322: Systemic lupus erythematosus
hsa-miR-17SLC39A8NM_022154Solute carrier family 39 (zinc transporter), member 8–0.69100.0089
hsa-miR-17CLIC5NM_016929Chloride intracellular channel 5–0.68870.0092
hsa-miR-20aKIAA0319NM_014809KIAA0319–0.67830.0108
hsa-miR-19aCEACAM8NM_001816Carcinoembryonic antigen-related cell adhesion molecule 8–0.67510.0114
hsa-miR-19aTRIM68NM_018073Tripartite motif-containing 68–0.67140.0120
hsa-miR-19aSFT2D3NM_032740SFT2 domain containing 3–0.66840.0125
hsa-miR-17GGT6NM_153338γ-glutamyltransferase 6–0.66760.012700430: Taurine and hypotaurine metabolism, 00450: Selenoamino acid metabolism, 00460: Cyanoamino acid metabolism, 00480: Glutathione metabolism, 00590: Arachidonic acid metabolism, 01100: Metabolic pathways
hsa-miR-20aXDHNM_000379Xanthine dehydrogenase–0.66730.012700230: Purine metabolism, 00232: Caffeine metabolism, 00983: Drug metabolism–other enzymes, 01100: Metabolic pathways
hsa-miR-20aPPARANM_005036Peroxisome proliferator-activated receptor α–0.66540.013103320: PPAR signaling pathway, 04920: Adipocytokine signaling pathway
hsa-miR-17C2orf15NM_144706Chromosome 2 open reading frame 15–0.66530.0131
hsa-miR-17GK5BX648681Glycerol kinase 5 (putative)–0.66340.0134
hsa-miR-17SIDT1NM_017699SID1 transmembrane family, member 1–0.66190.0137
hsa-miR-25ATP10BAB018258ATPase, class V, type 10B–0.66050.0140
hsa-miR-17TMC5NM_024780Transmembrane channel-like 5–0.65900.0143
hsa-miR-18aALDH1A2NM_170697Aldehyde dehydrogenase 1 family, member A2–0.65860.014400830: Retinol metabolism, 01100: Metabolic pathways
hsa-miR-17INADLNM_176877InaD-like (Drosophila)–0.65160.015804530: Tight junction

NOTE: Based on the computational analysis by TargetScan (ref. 19, 20).

  • aCorrelation coefficient <–0.65, P < 0.05 Ranked by correlation coefficient.

  • bKEGG, kyoto encyclopedia of genes and genomes (ref. 18).