Table 1.

BRAF mutation status according to characteristics of the primary melanoma (n = 301)

Mutant BRAF (n = 139)Wild-type BRAF (n = 162)
Primary typeNo. of patients (%)No. of patientsP
 Cutaneous115 (45)138 (55)P = 0.183
 Occult23 (55)19 (45)
 Mucosal1 (17)5 (83)
Histologic subtype
 Superficial spreading56 (64)31 (36)P< 0.001
 Nodular43 (50)43 (50)
 Desmoplastic2 (15)11 (85)
 Acral lentiginous0 (0)5 (100)
 Othera2 (18)10 (82)
 Not classified5 (50)5 (50)
 Missing data3157
Primary site
 Trunk54 (50)53 (50)P = 0.260
 Extremities37 (41)51 (59)
 Head and neck24 (42)34 (58)
 Occult23 (55)19 (45)
 Mucosal1 (17)5 (83)
Number of primary melanomas
 Occult or single127 (50)125 (50)P = 0.048
 Multiple11 (32)23 (68)
 Missing data114

NOTE: Seven of 308 patients did not have primary melanoma history data available (2%).

  • aOther includes mucosal SSM type (n = 2), mucosal lentiginous (WT = 1, Mut = 1), mixed (n = 1), malignant blue naevus (WT = 2, Mut = 1), lentigo maligna melanoma (n = 4).