Table 2.

92-Gene assay performance characteristics for tumor classification based on concordance with the adjudicated diagnosis

Tumor typeTested (N)Unc (N)Sensitivity (95% CI)Specificity (95% CI)PPVNPV
Adrenal2500.96 (0.80–1.00)0.99 (0.98–1.00)0.831.00
Brain2500.96 (0.80–1.00)1.00 (0.99–1.00)1.001.00
Breast2550.80 (0.56–0.94)1.00 (0.99–1.00)0.890.99
Cervix adenocarcinoma2570.72 (0.47–0.90)0.99 (0.99–1.00)0.760.99
Endometrium2540.48 (0.26–0.70)1.00 (0.99–1.00)1.000.99
Gastroesophageal2550.65 (0.41–0.85)0.99 (0.99–1.00)0.760.99
Germ cell2520.83 (0.61–0.95)1.00 (0.99–1.00)0.860.99
GIST2500.92 (0.74–0.99)1.00 (0.99–1.00)1.001.00
Head-neck-salivary2510.88 (0.68–0.97)0.99 (0.98–1.00)0.781.00
Intestine2550.85 (0.62–0.97)0.98 (0.97–0.99)0.611.00
Kidney3000.97 (0.83–1.00)1.00 (0.99–1.00)0.911.00
Liver2500.96 (0.80–1.00)1.00 (0.99–1.00)0.961.00
Lung-adeno/large cell2520.65 (0.43–0.84)1.00 (0.99–1.00)0.940.99
Lymphoma2500.84 (0.64–0.95)1.00 (0.99–1.00)0.950.99
Melanoma2500.88 (0.69–0.97)1.00 (0.99–1.00)0.961.00
Meningioma2501.00 (0.80–1.00)1.00 (0.99–1.00)1.001.00
Mesothelioma2520.87 (0.66–0.97)1.00 (0.99–1.00)1.001.00
Neuroendocrine5000.98 (0.89–1.00)1.00 (0.99–1.00)0.941.00
Ovary4040.86 (0.71–0.95)0.98 (0.97–0.99)0.690.99
Pancreaticobiliary3060.88 (0.68–0.97)0.99 (0.98–1.00)0.721.00
Prostate2501.00 (0.80–1.00)1.00 (0.99–1.00)1.001.00
Sarcoma6000.95 (0.86–0.99)0.99 (0.97–0.99)0.851.00
Sex cord stromal tumor2500.80 (0.59–0.93)1.00 (0.99–1.00)1.000.99
Skin basal cell2501.00 (0.80–1.00)1.00 (0.99–1.00)1.001.00
Squamous3010.86 (0.68–0.96)0.98 (0.97–0.99)0.660.99
Thymus2500.72 (0.51–0.88)1.00 (0.99–1.00)1.000.99
Thyroid2500.96 (0.80–1.00)1.00 (0.99–1.00)0.961.00
Urinary bladder2530.64 (0.41–0.83)0.99 (0.98–1.00)0.670.99
Overall0.87 (0.84–0.89)

Abbreviations: N, number of cases; Unc, unclassified by the 92-gene assay.