Table 4.

Clinical use of the 92-gene assay in discrimination of primary versus metastatic tumors

Lesion typePerformance for prediction of primary Tumor
Biopsy sitePrimary (n)Metastatic (n)Sensitivity (95% CI)Specificity (95% CI)PPV (%)NPV (%)
Lung346279 (0.62–0.91)100 (0.91–1.00)10090
Liver854100 (0.52–1.00)96 (0.87–1.00)80100
Brain503398 (0.89–1.00)100 (0.85–1.00)10097
Ovary36792 (0.78–0.98)57 (0.18–0.90)9257
Pleura/peritoneum194995 (0.74–1.00)100 (0.89–1.00)10098