Table 1.

Description of the macrophage and DC subsets in the tumor microenvironment of pediatric cHL and their association with PFS and OS

VariableLabeled cells/mm2Cases analyzed (%)5-Year PFS rate (%)Univariate analysis (P) for PFS5-Year OS rate (%)Univariate analysis (P) for OS
CD14+ (cells/mm2)
 Range0 to 524
 (Mean/median)(83.1/53)
 ≤23 (25th percentile)20/78 (25.6)78.90.8850.6
 >23 (25th percentile)58/78 (74.4)7587
 ≤53 (50th percentile)39/78 (50)80.60.384.60.6
 >53 (50th percentile)39/78 (50)71.488.6
CD68+ (cells/mm2)
 Range44 to 601
 (Mean/median)(290.81/284)
 ≤194 (25th percentile)20/81 (24.7)78.90.684.20.8
 >194 (25th percentile)61/81 (75.3)73.286.4
 ≤284 (50th percentile)43/81 (53.1)67.50.185.40.9
 >284 (50th percentile)38/81 (46.9)82.986.5
CD163+ (cells/mm2)
 Range0 to 560
 (Mean/median)(164.1/143)
 ≤76 (25th percentile)20/79 (25.3)84.20.2850.8
 >76 (25th percentile)59/79 (74.7)71.785.5
 ≤143 (50th percentile)40/79 (50.6)86.80.01589.70.2
 >143 (50th percentile)39/79 (49.4)61.880.6
CD207+ (cells/mm2)
 Range0 to 32
 (Mean/median)(4.32/2)
 =0 (25th percentile)49/76 (64.5)74.40.686.70.9
 >0 (25th percentile)27/76 (35.5)69.285.2
 ≤2 (50th percentile)39/76 (51.3)70.30.682.10.2
 >2 (50th percentile)37/76 (48.7)7590.9
CD83+ (cells/mm2)
 Range11 to 410
 (Mean/median)(66.9/55)
 ≤38 (25th percentile)21/79 (26.6)800.6900.6
 >38 (25th percentile)58/79 (73.4)7585.5
 ≤55 (50th percenstile)40/79 (50.6)77.80.783.80.6
 >55 (50th percentile)39/79 (49.4)7589.5