Table 1.

Clinical characteristics and molecular classes

Molecular class (N = 220)Molecular grade (N = 196)
VariableEntire cohort (N = 223)High-immune(n = 57)Normal-like (n = 63)Pigmentation (n = 84)Proliferative (n = 16)PLow-grade (n = 103)High-grade (n = 93)P
Age (range)a66 (14–101)66 (15–92)59 (14–86)70 (29–91)70 (41–100)0.0263 (15–91)69 (29–100)0.12
 ≤50 y4610181712418
 >50 y177474566157975
Gendera0.680.40
 Male114292944104951
 Female10928343965442
Mutation statusa
BRAF mutation3812141020.1725110.03
NRAS mutation23351140.167140.06
BRAF/NRAS wild-type6820152663332
Median thicknessa, (range), mm1.8 (0.6–25)1.6 (0.7–14)1.2 (0.6–4)3.4 (0.8–25)3.5 (1.1–12)<0.011.2 (0.7–14)3.5 (0.9–25)<0.01
Breslow thickness, na<0.01<0.01
 <1 mm34111940282
 1–2 mm6920331324512
 2–4 mm451452251326
 >4 mm4851346638
Site, na0.020.02
 Head/neck30491431017
 Trunk12841344686548
 Extremities3791682259
 Subungual183-93115
Melanoma type, na<0.01<0.01
 SSM10233402366923
 NM781594671850
 LMM206941106
 ALM5130100
 Mucosal132091111
Mitotic rate,a no. per mm2<0.01<0.01
 ≤6 mitoses per mm2135383746126754
 >6 mitoses per mm23012243227
Ulcerationa<0.01<0.01
 Present6810542101051
 Absent9529342655928
AJCC stage, 2009 editiona<0.01<0.01
 IA/B3/612300507
 IIA211940214911
 IIB342616417426
 IIC283083322
TILsa<0.01<0.01
 Absent543142961533
 Nonbrisk7616183482941
 Brisk3520771257
Clark levela<0.01<0.01
 II5230040
 III8319402145219
 IV9226164173747
 V153083210
  • aP values were calculated using a χ2, Mann–Whitney test, or ANOVA. Subungual site was excluded in the statistical analysis as were mucosal and Clark level II because of the low number of patients in each group.