Table 4.

Familial pancreatic cancer genes

GeneaChromosomeSyndrome nameOther tumor types
BRCA213qFamilial breast cancer 2Breast, ovary, and prostate
P16/CDKN2A9pFamilial atypical multiple mole melanomaMelanoma
PRSS17qFamilial pancreatitisNone
ATM11qAtaxia telangiectasiaLeukemia and lymphoma (homozygotes), breast (heterozygotes)
STK1119pPeutz-JeghersGastrointestinal tract, breast, gynecologic, testis, and lung

aThe BRCA2, p16/CDKN2A, STK11, ATM, PALB2, and PRSS1 genes account for less than 20% of the familial aggregation of pancreatic cancer.