Table 1.

Histopathology and genotypes of ROS1 IHC–positive samples

Tumor IDDiagnosisHistologic pattern (%)IHC ScoreROS1 FISHROS1 fusionEGFR mutation status
147AdenocarcinomaBAC (40), papillary (30), Acinar (20), Solid (10)3+ cytoplasmic+SLC34A2-ROS1L858R
306AdenocarcinomaAcinar (70), papillary (20), and solid (10)3+ cytoplasmic+CD74-ROS1
570AdenocarcinomaAcinar (90), BAC (5), micropapillary (5)3+ cytoplasmic, punctae+CD74-ROS1
760AdenocarcinomaSignet cells3+ cytoplasmic, membrane+Insufficient materialInsufficient material
400037AdenocarcinomaAcinar2+ cytoplasmic, punctae+CD74-ROS1
575Large Cell2+ cytoplasmicNot scoreableUnknown
668AdenocarcinomaSolid (80), Acinar (10), BAC (10)1+ cytoplasmic+CD74-ROS1
702AdenocarcinomaPapillary (40), Acinar (30), Solid (30)1+ cytoplasmic+SLC34A2-ROS1E746-A750del
749AdenocarcinomaSolid (80), Acinar (20)1+ vesicular+FIG-ROS1 (S)