Table 2.

Univariate analysis of ISCL/EORTC T-stage classification and effect of histologic and biochemical factors on OS, DSS, and PFS

OSDSSPFS
ClassificationHR (95% CI)PHR (95% CI)PHR (95% CI)P
T classification
T1a vs. T40.05 (0.03–0.09)<0.00010.01 (0.01–0.075)<0.00010.09 (0.05–0.14)<0.0001
T1b vs. T40.17 (0.11–0.28)0.21 (0.10–0.44)0.43 (0.30–0.62)
T2a vs. T40.08 (0.04–0.16)0.06 (0.02–0.19)0.14 (0.08–0.23)
T2b vs. T40.33 (0.23–0.47)0.31 (0.17–0.55)0.57 (0.43–0.77)
T3 vs. T40.68 (0.49–0.94)1 (0.62–1.61)0.75 (0.55–1.03)
N classification
N0 vs. N40.27 (0.17–0.45)<0.00010.22 (0.10–0.46)<0.00010.39 (0.24–0.62)<0.0001
N1 vs. N40.37 (0.19–0.75)0.32 (0.11–0.95)0.55 (0.29–1.04)
N2 vs. N40.98 (0.51–1.90)1.11 (0.42–2.92)0.99 (0.51–1.91)
N3 vs. N40.92 (0.40–2.13)1.09 (0.32–3.66)0.88 (0.38–2.03)
B classification
B0 vs. B20.19 (0.15–0.25)<0.00010.21 (0.14–0.32)<0.00010.29 (0.23–0.37)<0.0001
B1 vs. B20.11 (0.01–0.80)0.31 (0.04–2.27)0.51 (0.18–1.39)
M classification
M0 vs. M10.27 (0.19–0.38)<0.00010.18 (0.11–0.29)<0.00010.39 (0.28–0.54)<0.0001
Sezary syndrome
No vs. yes0.2 (0.15–0.25)<0.00010.21 (0.14–0.31)<0.00010.39 (0.28–0.54)<0.0001
Folliculotropic
No vs. yes1.19 (0.56–2.53)0.641.6 (0.39–6.5)0.51.07 (0.57–2.02)0.81
Poikiloderma
No vs. yes2.83 (1.26–6.37)0.016.7 (0.94–48.65)0.061.63 (0.94–2.85)0.08
Hypopigmented
No vs. yes1.56 (0.73–3.32)0.242.06 (0.50–8.39)0.31.51 (0.77–2.94)0.22
MF with Lyp
No vs. yes5.58 (1.38–22.42)0.024.23 (0.59–30.3)0.152.76 (1.14–6.69)0.02
LCT skin and node
No vs. yes0.13 (0.08–0.20)<0.00010.06 (0.03–0.13)<0.00010.33 (0.24–0.45)<0.0001
Tumor distribution
Localized vs. solitary0.81 (0.36–1.78)<0.00010.77 (0.23–2.52)<0.00011.06 (0.52–2.15)<0.0001
Regional vs. solitary0.87 (0.25–2.94)1.89 (0.51–7.02)0.73 (0.21–2.44)
Generalized vs. solitary1.34 (0.74–2.41)1.52 (0.65–3.56)1.17 (0.66–2.08)
LDH
Normal vs. high0.25 (0.19–0.32)<0.00010.22 (0.15–0.34)<0.00010.3 (0.24–0.37)<0.0001
WBC
Normal vs. high0.35 (0.25–0.48)<0.00010.27 (0.16–0.44)<0.00010.42 (0.31–0.56)<0.0001
Sex
Female vs. male0.84 (0.65–1.07)0.160.91 (0.16–1.36)0.670.87 (0.70–1.08)0.22
β2-Microglobulin
<1.8 vs. >1.80.153 (0.08–0.26)<0.00010.1 (0.03–0.28)<0.00010.22 (0.14–0.34)<0.0001
CD25 expression
<20% vs. >20%0.81 (0.58–1.15)0.250.73 (0.44–1.19)0.210.76 (0.56–1.03)0.09
CD30 expression
No vs. yes0.92 (0.57–1.49)0.760.98 (0.48–2.00)0.971.03 (0.67–1.59)0.87