Table 1.

Most frequent chromosome imbalances in PCNSL (candidate genes are listed in all regions smaller than 5 Mb)

Chromosome regionCytobandSize (Mb)EventCases, n (%)Genes, nGene symbols
chr6:32,561,968-32,616,499p21.320.1Loss23 (79)1HLA-DRB5
chr6:31,281,893-32,550,756p21.33-p21.321.3Loss9 (31)80
chr6:32,611,800-33,081,054p21.320.5Loss10 (34)16
chr6:102,757,131-104,010,647q16.31.3Loss11 (37)0
chr6:77,085,561-102,662,047q14.1-q16.325.6Loss8 (27)84
chr6:104,992,890-151,197,385q21-q25.146.2Loss10 (34)243
chr7:83,113,802-86,268,286q21.11-q21.123.2Gain6 (20)4SEMA3E; SEMA3A, SEMA3D, GRM3
chr7:113,788,480-115,513,297q31.1-q31.21.7Gain6 (20)3FOXP2, MDFIC, TFEC
chr12:37,332,160-91,334,471q12-q2254.0Gain8 (27)452