Table 2.

Dose-response treatment effect of s.c. xenografts of A2780-derived cell line

Dose-effect parametersb
TreatmentDose, mg/kgFraction affecteda, Fam (SD)Dmr
Lurbinectedin0.1800.29
0.1350.261.04 (0.16)2.120.978
0.0900.22
0.0450.09
Cisplatin6.00.45
4.50.311.24 (0.12)1.290.990
3.00.23
1.50.12
Lurbinectedin + cisplatin0.180 + 6.00.77
0.135 + 4.50.562.34 (0.36)1.200.977
0.090 + 3.00.50
0.045 + 1.50.10
  • aFraction affected (Fa = 1−T/C), defined as the change in tumor volume for each treated (T) and placebo (C) groups during placebo-treated survival period.

  • bDerived from the median-effect plot: [logFa/(1-Fa)] versus log(Dose), where m is the slope (as mean ± SD), Dm is the intercept of the plot, and r is the linear regression coefficient.