Dose-effect parameters^{b} | |||||
---|---|---|---|---|---|
Treatment | Dose, mg/kg | Fraction affected^{a}, F_{a} | m (SD) | D_{m} | r |
Lurbinectedin | 0.180 | 0.29 | |||
0.135 | 0.26 | 1.04 (0.16) | 2.12 | 0.978 | |
0.090 | 0.22 | ||||
0.045 | 0.09 | ||||
Cisplatin | 6.0 | 0.45 | |||
4.5 | 0.31 | 1.24 (0.12) | 1.29 | 0.990 | |
3.0 | 0.23 | ||||
1.5 | 0.12 | ||||
Lurbinectedin + cisplatin | 0.180 + 6.0 | 0.77 | |||
0.135 + 4.5 | 0.56 | 2.34 (0.36) | 1.20 | 0.977 | |
0.090 + 3.0 | 0.50 | ||||
0.045 + 1.5 | 0.10 |
↵^{a}Fraction affected (F_{a} = 1−T/C), defined as the change in tumor volume for each treated (T) and placebo (C) groups during placebo-treated survival period.
↵^{b}Derived from the median-effect plot: [logFa/(1-Fa)] versus log(Dose), where m is the slope (as mean ± SD), D_{m} is the intercept of the plot, and r is the linear regression coefficient.