Table 1.

Initiation of carcinogenesis, progression to cervical cancer, and overall cancer risk in HPV-positive and HPV-negative subsets by genetic models

N = number of studies (number of individuals)
OR (95% CI)
P value
HPV-positive subsetHPV-negative subset
Subset comparisonRecessiveDominantAdditiveRecessiveDominantAdditive
Initiation
High-grade SIL vs. controlN = 8 (1,370)N = 5 (1,131)N = 5 (1,131)N = 8 (1,958)N = 5 (1,746)N = 5 (1,746)
1.01 (0.68–1.49)1.40 (0.90–2.17)1.08 (0.82–1.44)1.17 (0.79–1.74)1.17 (0.73–1.86)1.12 (0.83–1.51)
P = 0.97P = 0.13P = 0.58P = 0.44P = 0.52P = 0.46
Low-grade SIL vs. controlN = 5 (465)N = 3 (173)N = 3 (173)N = 4 (461)N = 2 (272)N = 2 (272)
0.74 (0.48–1.15)0.15 (0.01–1.92)0.57 (0.29–1.12)0.88 (0.57–1.34)0.86 (0.40–1.85)0.93 (0.54–1.61)
P = 0.18P = 0.15P = 0.10P = 0.54P = 0.69P = 0.81
SIL (unspecified) vs. controlN = 5 (315)N = 5 (315)N = 5 (315)N = 8 (744)N = 8 (744)N = 8 (744)
1.45 (0.64–3.28)0.39 (0.15–1.04)0.90 (0.52–1.56)1.26 (0.75–2.09)1.03 (0.62–1.70)1.12 (0.77–1.62)
P = 0.37P = 0.06P = 0.70P = 0.38P = 0.91P = 0.56
WhiteN = 5 (775)N = 5 (775)N = 5 (775)N = 6 (1,316)N = 6 (1,316)N = 6 (1,316)
0.74 (0.47–1.14)0.35 (0.07–1.84)0.82 (0.58–1.14)0.96 (0.65–1.40)1.00 (0.65–1.55)0.91 (0.47–1.77)
P = 0.17P = 0.22P = 0.24P = 0.83P = 0.99P = 0.79
Any SIL vs. controlN = 14 (1,947)N = 11 (1,559)N = 11 (1,559)N = 16 (2,968)N = 12 (2,613)N = 12 (2,613)
0.96 (0.72–1.27)0.61 (0.30–1.25)0.97 (0.76–1.23)1.11 (0.88–1.41)1.05 (0.77–1.43)1.09 (0.88–1.35)
P = 0.78P = 0.17P = 0.78P = 0.39P = 0.75P = 0.44
Progression
Cervical cancer vs. high-grade SILN = 11 (1,110)N = 9 (985)N = 9 (985)N = 4 (277)N = 2 (101)N = 2 (101)
1.42 (1.09–1.84)1.05 (0.54–2.04)1.27 (0.94–1.72)0.74 (0.38–1.45)0.98 (0.31–3.16)1.03 (0.35–3.01)
P = 0.009P = 0.89P = 0.11P = 0.38P = 0.98P = 0.96
Cervical cancer vs. low-grade SILN = 10 (1,021)N = 9 (897)N = 9 (897)N = 3 (312)N = 2 (186)N = 2 (186)
1.63 (1.20–2.22)1.57 (1.03–2.40)1.44 (1.06–1.97)1.04 (0.31–3.51)1.01 (0.42–2.41)1.25 (0.56–2.79)
P = 0.002P = 0.04aP = 0.02aP = 0.94P = 0.98P = 0.58
Cervical cancer vs. SIL (unspecified)N = 7 (704)N = 7 (704)N = 7 (704)N = 6 (324)N = 6 (324)N = 6 (324)
1.02 (0.72–1.44)1.17 (0.73, 1.88)1.03 (0.73, 1.46)1.40 (0.79, 2.51)1.28 (0.61, 2.68)1.24 (0.70, 2.19)
P = 0.92P = 0.51P = 0.85P = 0.25P = 0.52P = 0.46
Cervical cancer vs. any SILN = 19 (2,339)N = 17 (2,093)N = 17 (2,093)N = 10 (793)N = 8 (571)N = 8 (571)
1.37 (1.15–1.62)1.30 (0.98–1.73)1.25 (1.04–1.51)0.98 (0.67–1.42)1.12 (0.68–1.86)1.21 (0.79–1.85)
P < 0.001P = 0.07P = 0.02aP = 0.90P = 0.66P = 0.39
Overall risk
HR-HPV onlyN = 15 (1,711)N = 11 (1,341)N = 11 (1,341)N = 15 (2,578)N = 12 (2,150)N = 12 (2,150)
0.82 (0.55–1.23)0.91 (0.65–1.29)0.86 (0.67–1.11)1.09 (0.67–1.76)1.14 (0.87–1.50)0.89 (0.73–1.10)
P = 0.33P = 0.60P = 0.25P = 0.73P = 0.33P = 0.29
Methodologically soundN = 11 (1,272)N = 9 (1,113)N = 9 (1,113)N = 10 (1,994)N = 9 (1,737)N = 9 (1,737)
0.70 (0.43–1.14)1.13 (0.75–1.68)0.85 (0.64–1.15)0.91 (0.49–1.69)1.14 (0.85–1.52)0.83 (0.66–1.04)
P = 0.15P = 0.56P = 0.30P = 0.76P = 0.39P = 0.11
Optimal tissue sourceN = 9 (1,218)N = 7 (1,005)N = 7 (1,005)N = 8 (1,816)N = 7 (1,711)N = 7 (1,711)
0.96 (0.53–1.76)1.01 (0.64–1.58)0.90 (0.66–1.22)0.67 (0.39–1.13)1.24 (0.92–1.67)0.83 (0.62–1.13)
P = 0.90P = 0.98P = 0.50P = 0.13P = 0.15P = 0.24
Optimal genotyping methodN = 12 (1,255)N = 9 (1,021)N = 9 (1,021)N = 13 (2,269)N = 11 (1,946)N = 11 (1,946)
0.82 (0.47–1.41)1.08 (0.72–1.63)0.89 [0.66–1.20]1.11 (0.66–1.89)1.11 (0.85–1.46)0.86 (0.70–1.07)
P = 0.47P = 0.71P = 0.44P = 0.69P = 0.44P = 0.18
WhiteN = 6 (661)N = 6 (661)N = 6 (661)N = 5 (455)N = 5 (455)N = 5 (455)
1.05 (0.78–1.43)0.86 (0.47–1.58)0.96 (0.66–1.39)1.36 (0.56–3.28)0.81 (0.32–2.02)1.08 (0.61–1.94)
P = 0.74P = 0.64P = 0.83P = 0.49P = 0.65P = 0.79
East AsianN = 6 (753)N = 3 (460)N = 3 (460)N = 6 (1,613)N = 3 (1,185)N = 3 (1,185)
1.00 (0.31–3.20)1.08 (0.66–1.79)0.82 (0.55–1.23)0.86 (0.42–1.76)1.36 (0.97–1.91)0.98 (0.55–1.75)
P = 1.00P = 0.75P = 0.34P = 0.69P = 0.07P = 0.96
Total: Cervical cancer vs. any controlN = 18 (2,001)N = 14 (1,631)N = 14 (1,631)N = 18 (2,829)N = 15 (2,401)N = 15 (2,401)
0.92 (0.63–1.33)0.94 (0.68–1.30)0.90 (0.71–1.14)1.07 (0.69–1.66)1.12 (0.86–1.45)0.90 (0.73–1.10)
P = 0.64P = 0.72P = 0.37P = 0.76P = 0.41P = 0.29
  • aNot significant upon consideration of the Bonferroni-corrected P value (P < 0.0083).