Table 3.

Dose escalation and clinical outcome for 24 adults with relapsed or refractory acute leukemia

SCH 900776 dose levelDay 14 CTCResponse (CR/CRi)Response in pts with prior cytarabine
1. 10 mg/m2 (n = 3)11 (0/1): AML1 (high)a
2. 20 mg/m2 (n = 3)10 (0/0)0
3. 40 (mg/m2 (n = 6)43 (2/1): all AML2 (both high)
4. 56 (mg/m2 (n = 6)32 (2/0): both AML2 (1 high)
5. 140 mg (n = 6)32 (1/1): both AML2 (both high)
Total128 (5/3): all AML7 (6 high)
  • aCytarabine 2 g/m2/72 hours infusion or high dose (2–3 g/m2 given every 12 hours for 6–12 doses).