Table 1.

Baseline characteristics of the population

Training set (n = 84)Test set (n = 42)Small HCC projections (n = 28)
Cirrhosis (n = 62)Large HCC (n = 22)Cirrhosis (n = 31)Large HCC (n = 11)
Age, ya59.0 ± 1.471.7 ± 1.7c59.5 ± 2.266.3 ± 2.566.7 ± 1.3c
Male genderb53 (85%)22 (100%)c27 (81%)11 (100%)22 (28%)
ALT (UI/L)a41.1 ± 2.553 ± 11.447.0 ± 7.838.5 ± 7.249.5 ± 12.2
AST (UI/L)a75.9 ± 6.897.3 ± 26.772.4 ± 12.454.5 ± 5.962.0 ± 7.5
Albumin (g/L)a38.9 ± 0.737.3 ± 1.037.9 ± 1.237.7 ± 1.539.8 ± 1.0
Prothrombin level (% control)a72.5 ± 2.275.4 ± 3.770.0 ± 3.569.1 ± 4.769.9 ± 2.7
Bilirubin (μmol/L)a23.6 ± 3.317.9 ± 2.129.4 ± 4.126.6 ± 8.717.1 ± 1.7
Child–Pugh scorea5.8 ± 0.16.0 ± 0.26.3 ± 0.26.2 ± 0.35.5 ± 0.2c
MELD scorea11.3 ± 0.511.1 ± 1.011.9 ± 0.813.4 ± 2.110.5 ± 0.8
Creatinine, μmol/La87.0 ± 4.8101.3 ± 8.679.2 ± 3.1136.1 ± 40.5c82.2 ± 5.5
Blood glucose, mmol/L6.3 ± 0.36.1 ± 0.38.0 ± 0.97.0 ± 0.96.3 ± 0.4
Triglyceride, g/La1.1 ± 0.11.5 ± 0.31.5 ± 0.21.2 ± 0.11.1 ± 0.1
Total cholesterol, mmol/La4.4 ± 0.24.9 ± 0.64.6 ± 0.35.0 ± 0.64.8 ± 0.3
AFP, ng/mLa10.3 ± 3.16,156.2 ± 3,947.6c18.0 ± 4.05,665.2 ± 5,484.3179.4 ± 178.3d
HCC characteristics
Number of nodules2.4 ± 0.33.6 ± 0.81.2 ± 0.1d
Size (mean sum of nodules, mm)93.1 ± 9.4100.1 ± 12.231.9 ± 2.9d
PVT (number, %)1 (2%)8 (36%)2 (18%)0 (0%)
Metastasis (number, %)3 (14%)1 (9%)0 (0%)

NOTE: All biologic and clinical parameters were recorded at inclusion.

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; PVT, portal vein thrombosis.

  • aMean ± SEM.

  • bNumber (percentage) of patients.

  • cP < 0.05 between HCC and cirrhosis.

  • dP < 0.05 between large and small HCC groups.