Table 2.

Grade 3 to 4 nonhematologic toxicities

Category10 mg/m2 (n = 3)20 mg/m2 (n = 3)40 mg/m2 (n = 6)56 mg/m2 (n = 6)140 mg (n = 6)
Cardiac: QTcF prolongation1/6a
Gastrointestinal: mucositis1/6
Liver: hyperbilirubinemiab1/32/61/6
Skin: hand–foot syndrome1/31/6c
  • aPlus 1 additional patient with transient (<30 minute) grade 3 QTcF > 500 milliseconds.

  • bAll grade 3 and resolved within 48 hours.

  • cProlonged (>7 days).