Table 4.

Rilotumumab pharmacokinetic parameter estimates

Cmin, μg/mLCmax, μg/mL
CyclenMean (SD)CV%nMean (SD)CV%
Rilotumumab (7.5 mg/kg) + MP
 1400 (0)NC36180 (35.1)19.5
 33295.1 (26.1)27.529280 (70.7)25.3
 525125 (35.2)28.022297 (74.8)25.2
 711129 (40.2)31.210256 (111)43.1
Rilotumumab (15 mg/kg) + MP
 1450 (0)NC41355 (90.4)25.5
 343182 (55.3)30.340562 (157)27.9
 525241 (103)42.919609 (126)20.6
 715301 (112)37.325655 (175)26.7

Abbreviations: CV, coefficient of variation; NC, not calculated.