Table 1.

Axl inhibition reverses EGFR resistance in mesenchymal cell lines

A549Calu-1H157H1299H460H2882
Erlotinib IC50, μmol/L13.54>10048.50>100>100>100
SGI-7079 IC50, μmol/L0.922.440.741.742.014.29
CI @IC500.46>1.00a0.670.720.57>1.00a
Combination: erlotinib + SGI-7079 IC50, μmol/L1.07 + 0.3513.86 + 4.471.46 + 0.473.76 + 1.213.53 + 1.1416.44 + 5.30
  • aFor Calu-1 and H2882, the combination was antagonistic at IC50 but synergistic at higher concentration of SGI-7079.