Table 5.

Association between CYP2D6 phenotype and disease event during the 5 years of drug therapy in arms A and B

Tamoxifen only (arm A)Tamoxifen followed by anastrozole (arm B)
OR (95% CI)POR (95% CI)P
PM/PM relative to EM/EM2.45 (1.05–5.73)0.040.60 (0.15–2.37)0.47
EM/PM and PM/IM relative to EM/EM1.67 (0.95–2.93)0.070.76 (0.43–1.31)0.32
EM/IM and IM/IM relative to EM/EM1.23 (0.58–2.61)0.601.02 (0.52–2.01)0.96