Table 1.

Association between clinicopathologic variables and activation of Akt-mTOR and MAPK pathways

p-Aktp-mTORp-S6RPp-p70S6Kp-4E-BP1p-MEK1/2p-ERK1/2
VariableNo. of patientsPositiveNegativeP valuePositiveNegativeP valuePositiveNegativeP valuePositiveNegativeP valuePositiveNegativeP valuePositiveNegativeP valuePositiveNegativeP value
Clinical variables (primary cases, n = 91)
Age, y
 <505031190.4224260.8728220.6529210.8631190.894640.69#4280.47
 ≥504122191922212023182615392329
Sex
 Male4628180.6121250.7622240.2430160.1131150.344331.00#3970.43
 Female45252022232718222326194233510
NF1
 Present3723140.5314230.1420170.9718190.1820170.163521.00#2890.26
 Absent5430242925292534203717504468
Site
 Extremity3923160.90a19200.81a20190.67a23160.76a28110.14a3720.70a,#3270.88a
 Trunk wall2314991415813101310212167
 Head and neck/retroperitoneum/visceral/spine2916131514141516131613272263
Tumor depth
 Superficial218130.034*4170.0053*,#6150.0076*10110.329120.035*2100.33#1290.0024*
 Deep7045253931432742284822646628
Tumor size, cm
 <52515100.8311140.7012130.491780.191780.512411.00#1960.43
 ≥566382832343729353140266155511
Adjuvant therapy
 Given4310.64#221.00#310.62#400.13#311.00#401.00#401.00#
 Not given87503741464641483954338167017
AJCC staging
 I2816120.89b11170.31b15130.97b16121.00b15130.24b2621.00b,#2170.31b
 II4125162318202126152813383347
 III179871010789134170161
 IV532234123144132
Pathologic variables (all cases, n = 135)
Tumor necrosis
 No necrosis6432320.082c29350.34c33310.29c37270.51c35290.058c5860.053c,#43210.083c
 <50%54361832223321371743115314311
 ≥50%1710761110789710170143
Mitotic counts
 0–9/10 HPF8648380.54d39470.19d49370.83d48380.12d47390.0069*,d8060.42d,#56300.0019*,d,#
 10–19/10 HPF17143143107152152170152
 ≥20/10 HPF321616141817151913239311293
Ki-67 labeling index
 0%–9%3113180.0026*,e14170.088e17140.54e20110.53e16150.16e2830.42e,#20110.26e
 10%–29%59312826333227332637225634415
 ≥30%4534112718271829163213441369
Rhabdomyoblastic differentiation
 Present161150.43#4120.060#790.30#5110.014*,#790.10#1420.19#970.12#
 Absent1196752635669507742784111459128
Epithelioid feature
 Present8710.14#350.72#440.73#440.71#440.47#710.35#530.43#
 Absent1277156646372557849814612169532
Histologic grade
 Low-grade4221210.2216260.07124180.8923190.3420220.014*4021.00#25170.011*
 High-grade93573651425241593465288857518
  • *Statistically significant.

  • #Fisher exact test was used.

  • aComparison of extremity and the others.

  • bComparison of stage I and II to IV.

  • cComparison of no necrosis and presence of necrosis.

  • dComparison of 0–9/10 HPF and ≥10/10 HPF.

  • eComparison of 0%–29% and ≥30%.