Table 3.

Association between htSNPs in candidate steroidogenic pathways and BCR in Caucasians (n = 526)

Cox regression analysesb
HeterozygousHomozygousBest-fitting genetic models
SNPMajorMinorMAFBCRaNo-BCRaHR (95% CI)PHR (95% CI)PModelHR (95% CI)P
CYP17A1
 rs1004467TTCC7%1/11/1181/58/3320.50 (0.25–1.01)0.0520.69 (0.09–5.15)0.72Dom0.52 (0.27–1.00)0.051
 rs2486758TTCC22%9/55/6519/123/2501.82 (1.24–2.68)0.0021.50 (0.71–3.19)0.29Dom1.77 (1.22–2.57)0.003
 rs6162AAGG59%65/49/16143/204/460.71 (0.39–1.31)0.271.19 (0.66–2.13)0.60Rec1.54 (1.07–2.24)0.022
 rs743572GGAA65%66/47/16150/199/430.69 (0.38–1.27)0.241.17 (0.65–2.11)0.60Rec1.56 (1.07–2.26)0.020
CYP19A1
 rs1870050AACC6%0/20/1102/40/351Dom2.03 (1.22–3.38)0.006
 rs2446404AAGG6%0/18/1121/39/345Dom2.04 (1.20–3.47)0.008
ESR1
 rs1062577TTAA11%1/33/962/75/314Dom2.10 (1.38–3.22)0.0006
 rs2982683CCTT30%13/61/5430/162/1981.07 (0.72–1.58)0.751.85 (0.98–3.51)0.06Rec1.80 (0.98–3.29)0.06
 rs3003922GGCC20%2/41/8714/133/2470.92 (0.62–1.37)0.680.26 (0.06–1.09)0.06Rec0.27 (0.06–1.11)0.07
 rs488133CCTT33%17/56/5740/170/1810.87 (0.58–1.29)0.491.73 (0.97–3.09)0.06Rec1.86 (1.08–3.20)0.026
 rs9341016TTCC4%1/15/1141/24/360Dom1.98 (1.15–3.39)0.013

NOTE: If there were too few individuals being minor-allele homozygotes, illustrated by shades of gray, they were combined with heterozygotes. Significant associations in HSD17B2 and HSD17B3 were reported elsewhere (17). Bold, significant P values.

Abbreviations: Dom, dominant model; Rec, recessive model.

  • aThe number represents minor allele homozygotes, heterozygotes, and major allele homozygotes, respectively.

  • bMultivariate models included PSA at diagnosis, pathologic Gleason score, pathologic T stage, age at diagnosis, neoadjuvant therapy, smoking status, adjuvant therapy, surgical margins status, and nodal invasion status. The major allele homozygotes were considered as the reference group, with a fixed HR = 1.00.